34 research outputs found

    Phosphorus Efficiency Of Bornean Rain Forest Productivity: Evidence Against The Unimodal Efficiency Hypothesis

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117012/1/ecy20058661548.pd

    Biodiversity Conservation in the REDD

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    Deforestation and forest degradation in the tropics is a major source of global greenhouse gas (GHG) emissions. The tropics also harbour more than half the world's threatened species, raising the possibility that reducing GHG emissions by curtailing tropical deforestation could provide substantial co-benefits for biodiversity conservation. Here we explore the potential for such co-benefits in Indonesia, a leading source of GHG emissions from land cover and land use change, and among the most species-rich countries in the world. We show that focal ecosystems for interventions to reduce emissions from deforestation and forest degradation in Indonesia do not coincide with areas supporting the most species-rich communities or highest concentration of threatened species. We argue that inherent trade-offs among ecosystems in emission reduction potential, opportunity cost of foregone development and biodiversity values will require a regulatory framework to balance emission reduction interventions with biodiversity co-benefit targets. We discuss how such a regulatory framework might function, and caution that pursuing emission reduction strategies without such a framework may undermine, not enhance, long-term prospects for biodiversity conservation in the tropics

    Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

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    Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

    Gut microbiota-bile acid-skeletal muscle axis

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    The gut microbiota represents a 'metabolic organ' that can regulate human metabolism. Intact gut microbiota contributes to host homeostasis, whereas compositional perturbations, termed dysbiosis, are associated with a wide range of diseases. Recent evidence demonstrates that dysbiosis, and the accompanying loss of microbiota-derived metabolites, results in a substantial alteration of skeletal muscle metabolism. As an example, bile acids, produced in the liver and further metabolized by intestinal microbiota, are of considerable interest since they regulate several host metabolic pathways by activating nuclear receptors, including the farnesoid X receptor (FXR). Indeed, alteration of gut microbiota may lead to skeletal muscle atrophy via a bile acid-FXR pathway. This Review aims to suggest a new pathway that connects different mechanisms, involving the gut-muscle axis, that are often seen as unrelated, and, starting from preclinical studies, we hypothesize new strategies aimed at optimizing skeletal muscle functionality

    PHOSPHORUS EFFICIENCY OF BORNEAN RAIN FOREST PRODUCTIVITY: EVIDENCE AGAINST THE UNIMODAL EFFICIENCY HYPOTHESIS

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117012/1/ecy20058661548.pd

    An Ecological and Economic Assessment of the Nontimber Forest Product Gaharu Wood in Gunung Palung National Park, West Kalimantan, Indonesia

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    Ecological and economic data are essential to the identification of tropical nontimber forest products with the potential for sustainable and profitable extraction in a managed system. We studied the demographic effect and economic returns of harvesting aromatic gaharu wood from fungus-infected trees of Aquilaria malaccensis Lam. at Gunung Palung National Park, Indonesia, to evaluate the management potential of gaharu wood. Aquilaria malaccensis trees openface> 20 cm in diameter occurred at low preharvest densities (0.16 0.32 ha) but were distributed across five of six forest types surveyed. During a recent harvest, 75 of trees were felled, with harvest intensities ranging from 50 to 100 among forest types. Overall, 50 of trees contained gaharu wood, but trees at higher elevations contained gaharu wood more frequently ( 73 ) than trees at lower elevation (27 ). The mean density of regeneration ( juveniles> 15 cm in height) near adult trees (3 7 m away) was 0.2/m 2 , 200 times greater than at random in the forest (10/ha), but long-term data on growth and survivorship are needed to determine whether regeneration is sufficient for population recovery. Gaharu wood extraction from Gunung Palung was very profitable for collectors, generating an estimated gross financial return per day of US 8.80, triple the mean village wage. Yet, the estimated sustainable harvest of gaharu wood at natural tree densities generates a mean net present value of only 10.83/ha, much lower than that of commercial timber harvesting, the dominant forest use in Kalimantan. Returns per unit area could be improved substantially, however, by implementing known silvicultural methods to increase tree densities, increase the proportion of trees that produce gaharu wood, and shorten the time interval between successive harvests. The economic potential of gaharu wood is unusual among nontimber forest products and justifies experimental trials to develop small-scale cultivation methods.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74107/1/j.1523-1739.2001.98586.x.pd

    CSR, oil palm and the RSPO: translating boardroom philosophy into conservation action on the ground

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    Effective corporate social responsibility (CSR) is becoming mainstream strategic business planning for the oil palm industry. At its core, CSR aims to align business values with the needs and expectations of a broader range of stakeholders, beyond just investors and shareholders. In oil palm, this entails taking responsibility for social and environmental impacts, often beyond what is required by law, to build social and environmental capital in pursuit of a local "license to operate." Third-party certification standards are a popular tool for guiding and monitoring the impact of CSR programs and have taken root in oil palm through the multi-stakeholder Roundtable on Sustainable Palm Oil (RSPO). Eight years running, the RSPO has made substantial inroads to improve the environmental and social performance of Southeast Asia's largest and fastest growing plantation industry. Yet serious challenges remain for RSPO to mainstream environmentally sustainable and socially responsible practices throughout the supply chain. Based on experiences working with multi-stakeholder groups to implement RSPO, including industry, government, local communities, and NGOs, we highlight areas where change is required not only among growers but also the broader RSPO membership to build on recent achievements and accelerate progress. Major challenges include (1) improving corporate governance of plantation companies to translate boardroom CSR decisions into conservation actions on the ground; (2) pushing RSPO member processors, traders, manufacturers, and retailers, who profit from palm oil, to share the cost burden of implementing sustainability, (3) strengthening NGO partnerships with companies to provide the social and environmental expertise companies require but still lack, and (4) creating a more supportive regulatory structure in producer countries to implement sustainability. Challenges to RSPO progress can be overcome, but will require coordinated action to ensure that the scale and pace of change is sufficient to deliver long-term benefits for the environment before it is too late
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